iKnow

nano-Encapsulation of Proteins and Peptides
Research Output | Dar Al-hikmah Library | IIUM Only

The significance of protein and peptide use as therapeutic agents in parallel with conventional drugs has long been established with the use of insulin, growth hormones and antibiotics for treatment of diseases. Proteins and peptides offer high specificity, precise function and low immune response from the body. These therapeutic molecules are admi

Relation Between Apoe Gene Polymorphism and Coronary Artery Disease in South East and East Asian Countries
Research Output | Dar Al-hikmah Library | IIUM Only

Background and objective: Apolipoprotein E (apoE) is a polymorphic protein with vital antioxidant and anti-atherosclerotic effects. Three apoE isoforms exist due to polymorphisms in its gene causing disturbances of lipoproteins metabolism and a probability to develop cardiovascular diseases. The aim of this study was to assess the association betwe

Expression of Collagenases Matrix Metalloproteinases and Yb-1 Oncogenic Factor in Malignant Melanoma Cancer Cells and its Regulation by Stromal Fibroblasts
Research Output | Dar Al-hikmah Library | IIUM Only

Background and Objective: Fibroblast stromal cells actively participates in tumor invasion by secreting matrix metalloproteinases (MMPs) within the tumor microenvironment. Expression of these enzymes is primarily regulated at a transcriptional level via interaction with transcription factors. Among these factors, YB-1 oncogenic factor binds with di

Endothelial Nitric Oxide Synthase Gene Polymorphism and Coronary Arrtery Disease in Asian Populations
Research Output | Dar Al-hikmah Library | IIUM Only

Background and Objectives: Glu298Asp endothelial Nitric Oxide Synthase (eNOS) gene polymorphism results in a reduced bioavailability of Nitric Oxide (NO) & prones to atherosclerosis. Even though there were more than 15 studies conducted on Asian populations investigating the role of this polymorphism in coronary artery disease (CAD), however; t

Performance Comparison Between Archimedean and Equiangular Spiral Antenna
Research Output | Dar Al-hikmah Library | IIUM Only

Spiral antennas are commonly used in communication systems due to their compact size, wide bandwidth and circularly-polarized radiation. This paper shows the design, simulation and analysis of two different types of spiral antenna; the Archimedean and Equiangular spiral. The spirals were designed to be working in the frequency range of 1–4 GHz us

ngs-Data Analysis for Netagenome Cellulose- and Xylan- Degrading Enzymes Finding
Research Output | Dar Al-hikmah Library | IIUM Only

Abstract. For the aim of finding cellulose- and xylan-degrading enzymes needed in green industry to produce biofuel from plant biomass, a metagenomic DNA library from palm oil mill effluent (POME) was constructed and high-throughputly screened. The positive clones’ DNA were sequenced with next generation sequencing and raw data (short insert-pair

ultra-High-throughput Screening of Beta Glucoside Kinase Random Mutagenesis Library for phosphorus-Sulfur Bond Formation
Research Output | Dar Al-hikmah Library | IIUM Only

Abstract. In the continual quest of novel biocatalysts with improved properties that will fulfil the raising industrial demands, directed evolution appears to be one of the most powerful tools in generating novel enzymes. Error -Prone PCR is a customized PCR protocol that will randomly introduce mutations creating a variant library. Beta glucoside

"دراسة تقويمية للمحتوى الثقافي في كتاب "العربية بين يديك
Research Output | Dar Al-hikmah Library | IIUM Only

تهدف هذه الدراسة إلى تقويم المحتوى الثقافي في كتاب "العربية بين يديك" وذلك من خلال استنباط معايير مشتركة بين معايير رشدي أحمد طعيمة، ومعايير المجلس الأمريكي لمعلمي اللغات الأجنبية، ومعاي�

Current Progress in non-Viral Vectors for Cancer Gene Therapy
Research Output | Dar Al-hikmah Library | IIUM Only

Cancers are generally treated by radiotherapy, chemotherapy and radical surgery alone, or combination of these treatments. Selection of the treatment, depending on the type, location, size and stage of tumor. However, such conventional therapies are non-selective and can cause damage to normal tissue. Cancer gene therapy is a treatment method that

تفعيل آليّات ضمان المضارب والمشارك في ضوء مقصد حفظ المال
Research Output | Dar Al-hikmah Library | IIUM Only

من مقاصد الشريعة مبدء حفظ المال وعدم إتلافه، لأن به قوام الحياة، ومع أنه مقصد إسلامي فهو أيضا فطرة بشرية، ولهذا فقد اشتمل الدين الإسلامي العديد من التشريعات التي تؤسس أحكاما كثيرة تقصد كلها إل

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