Context: High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer–plasticizer carrier significantly affects drug solubility and tableting property of SD. Objective: To evaluate and optimize the combined effect of a binary carrier consisting PVP K30 and poloxamer 188, on

Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in human (Homo sapiens) cells. Our data indicate that ea

The present study investigates the response of implantable rotary blood pump (IRBP)-assisted patients to exercise and head-up tilt (HUT), as well as the effect of alterations in the model parameter values on this response, using validated numerical models. Furthermore, we comparatively evaluate the performance of a number of previously proposed phy

Clinacanthus nutans is a medicinal herb and a traditional remedy for herpes viral infection, cancer, and diabetes mellitus. Despite its popular use, there is limited information on the chemical constituents and their relationship with the bioactivities of the herb. The choice of drying and extraction methods will greatly influence the metabolite pr

tIpomoea aquatica Forsk is a green leafy vegetable that is a rich source of secondary metabolites, vitaminsand amino acids with many health benefits. Proton Nuclear Magnetic Resonance (1H NMR) spectroscopywas combined with multivariate data analyses to distinguish Ipomoea aquatica samples at different devel-opmental stages. A principal component an

A series of twenty-four 2-benzoyl-6-benzylidenecyclohexanone analogs were synthesized and evaluated for their nitric oxide inhibition and antioxidant activity. Six compounds (3, 8, 10, 17, 18 and 19) were found to exhibit significant NO inhibitory activity in LPS/IFN-induced RAW 264.7 macrophages, of which compound 10 demonstrated the highest activ

In this study we used common weed plant Commelina nudiflora as reducing and stabilizing agent for gold nanoparticles synthesis. The synthesized gold nanoparticles were characterized using their physical– chemical parameters such as size, shape, composition and crystalline nature by different analytical techniques. Biosynthesized gold nanoparticle

In this present study, we reported broccoli (Brassica oleracea L.) as a potential candidate for the synthesis of gold and silver nanoparticles (NPs) in green chemistry method. The synthesized metal nanoparticles are evaluated their antimicrobial efficacy against different human pathogenic organisms. The physico-chemical properties of gold nanoparti

Nisoldipine is a very potent calcium channel blocker which is used as anti-hypertensive agent. Although it is prescribed widely as oral tablet, its use has been limited due to poor bioavailability which arises from its poor water solubility. Hot Melt solid dispersion of poorly water-soluble drug in long chain polymer is a common approach to enhance

Keterlibatan pelajar telah diketahui secara positif berkaitan dengan prestasi akademik, tetapi terdapat kekurangan kajian yang menyerlahkan fenomena ini di kalangan mahasiswa Malaysia. Kajian ini bertujuan untuk mengkaji struktur faktor Student Engagement Instrument (SEI) dengan sampel pelajar di Malaysia. Alat kajian telah ditadbirkan kepada 290 p