Research Output | Dar Al-hikmah Library | IIUM Only
Background: Non-erosive reflux disease (NERD) is the most common phenotype of gastro esophageal reflux disease. Dilated intercellular spaces (DIS) in prickle cell layers are considered as early signs of acid damage to the esophageal epithelium. In order to enter the mucosal intercellular spaces, acid and pepsin have to penetrate the intercellular a