Introduction The murine double minute 2 (MDM2) gene encodes a regulatory protein of the p53 pathway. A single nucleotide polymorphism (T to G change) at position 309 (SNP309) in the promotor region of MDM2 affects the transcription activity of MDM2 and has been found to be a negative prognostic marker in several cancers. Patients and methods In thi

Entomology has been deeply rooted in various cultures since prehistoric times for the purpose of agriculture. Nowadays, many scientists are interested in the field of biodiversity in order to maintain the diversity of species within our ecosystem. Out of 1.3 million known species on this earth, insects account for more than two thirds of these know

Independent advice circulars are required in a broad range of corporate transactions. The advice circulars are extensively used in takeovers and mergers of companies. The board of directors of the target company is required to appoint an independent adviser to prepare the independent advice circular, in order to assist the shareholders of the targe

In this study, the reduction of free fatty acid (FFA) in low grade palm oil (LGPO) was conducted at various sonication times, ranging from 30 to 300 min. Screening of various acids was reported and selected acid was considered for further study. The results found that strong acids such as sulfuric acid to be superior to other acids. The FFA content

Previously, researchers had initiated investigation to find an alternative drug that can treat diabetes mellitus without dragging patients into more complicated health problems. After many studies, they found a new and high potential plant-based drug named stevia that is able to reduce diabetic patients’ blood glucose. This study aimed to determi

Pharmaceutical is a highly regulated industry based on its nature that involves human life. Every decision must be scientifically sound from the early stage in order to provide security and safety to the patient. Only 1 from 4000 synthesized drugs reach the market which cost about $800-900 million dollar within 8-12 years from discovery to market.

The aim of the present study is to investigate the effect of operating parameter of a Buchi B290 mini spray dryer towards specific activity of recBromelain. Using Response Surface Methodology (RSM), face centred central composite design (FCCCD) was tabulated for optimization. Optimization process was conducted by varying the inlet air temperature (

Micro jets are used in the present experimental study as an active control. Flow from converging nozzle to suddenly expanded circular duct of larger cross-sectional area than that of nozzle exit area were studied experimentally, focusing attention on the base pressure and the flow development in the duct. Mach number and nozzle pressure ratio are c

Introduction: This is a cross-sectional study of 37 patients with AO type C (complete intra-articular) fractures of the distal radius, evaluating the functional, anatomical, and patient rated outcomes one year after primary fixation with a volar locking plate. Methods: Functional outcomes were assessed based on the grip strength, and the range of m

Poly(lactic acid) (PLA) is a biodegradable polymer which has good mechanical properties, however, its brittleness limits its usage especially in packaging materials. Therefore, in this work, PLA based polyurethane films were prepared by synthesizing with different types of isocyanates; methylene diisocyanate (MDI) and hexamethylene diisocyanates (H