Herein we report for the first time a series of 2-benzamido-N-(2-oxo-4-(methyl/trifluoromethyl)-2H-chromen-7-yl) benzamide 3a–f and substituted quinazolin-4(3H)-ones and 2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxides (5, 6, 8 and 10a–c) as selective inhibitors of the tumor associated hCA IX and XII isoforms. Among the compounds reported th

We report a series of novel metanilamide-based derivatives 3a–q bearing the 2-mercapto-4-oxo-4H-quinazolin-3-yl moiety as tail. All compounds were synthesized by means of straightforward condensation procedures and were investigated in vitro for their inhibition potency against the human (h) carbonic anhydrase (CA; EC 4.2.1.1.1) isoforms I, II, I

A measurement of the double-differential inclusive jet cross section as a function of the jet transverse momentum p T and the absolute jet rapidity |y| is presented. Data from LHC proton-proton collisions at s = 8 $$ \backslashsqrt{s}=8 $$ TeV, corresponding to an integrated luminosity of 19.7 fb−1, have been collected with the CMS detector. Jets

Properties of the Higgs boson are measured in the H → ZZ → 4` (` = e, µ) decay channel. A data sample of proton-proton collisions at √ s = 13 TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb−1 is used. The signal strength modifier µ, defined as the ratio of the observed Higgs boson r

The transverse momentum spectra of weak vector bosons are measured in the CMS experiment at the LHC. The measurement uses a sample of proton-proton collisions at s=8 TeV, collected during a special low-luminosity running that corresponds to an integrated luminosity of 18.4 ± 0.5 pb−1. The production of W bosons is studied in both electron and mu

Jet charge is an estimator of the electric charge of a quark, antiquark, or gluon initiating a jet. It is based on the momentum-weighted sum of the electric charges of the jet constituents. Measurements of three charge observables of the leading jet in transverse momentum pT are performed with dijet events. The analysis is carried out with ata coll

Pair production of Υ(1S) mesons is observed at the LHC in proton-proton collisions at √ s = 8 TeV by the CMS experiment in a data sample corresponding to an integrated luminosity of 20.7 fb−1 . Both Υ(1S) candidates are fully reconstructed via their decays to µ +µ −. The fiducial acceptance region is defined by an absolute Υ(1S) rapidity

Cross sections for the production of a Z boson in association with jets in proton-proton collisions at a centre-of-mass energy of √ s = 8 TeV are measured using a data sample collected by the CMS experiment at the LHC corresponding to 19.6 fb−1 . Differential cross sections are presented as functions of up to three observables that describe the

Cardiovascular effects (e.g., tachycardia, hypo- and/or hypertension) are often clinical outcomes of snake envenoming. Malayan krait (Bungarus candidus) envenoming has been reported to cause cardiovascular effects that may be related to abnormalities in parasympathetic activity. However, the exact mechanism for this effect has yet to be determined.

A measurement of the t¯t production cross section at √ s = 13 TeV is presented using proton-proton collisions, corresponding to an integrated luminosity of 2.2 fb−1 , collected with the CMS detector at the LHC. Final states with one isolated charged lepton (electron or muon) and at least one jet are selected and categorized according to the ac