Research Output | Dar Al-hikmah Library | IIUM Only
DNA methylation silences the gene through addition of methyl group. p16, a tumor suppressor gene that inhibits cyclin-dependent kinase, inactivates the Rb protein and blocks G1 phase in a normal cell cycle. A DNA repair gene, MGMT removes alkyl adduct to a cysteine residue within the protein, thus preventing lethal cross-links. p16 and MGMT methyla