Research Output | Dar Al-hikmah Library | IIUM Only
The non-stereospecific α-haloalkanoic acid dehalogenase E (DehE) degrades many halo- genated compounds but is ineffective against β-halogenated compounds such as 3- chloropropionic acid (3CP). Using molecular dynamics (MD) simulations and site-directed mutagenesis we show here that introducing the mutation S188V into DehE improves sub- strate spe